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Some differences originate in events occurring in the intrauterine environment, where developmental processes differentially organize tissues for later activation in the male or female. In the prenatal period, sex determination and differentiation occur in a series of sequential processes governed by genetic and environmental factors. During the pubertal period, behavioral and hormonal changes manifest the secondary sexual characteristics that reinforce the sexual Free discreet without Elizabeth of the individual through adolescence and into adulthood. Hormonal events occurring in puberty lay a framework for biological differences that persist through life and that contribute to variable onset and progression of disease in males and females.

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X marks the spot: why the 'weaker sex' wins at every stage of life

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