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The strengths and weaknesses of these approaches are summarized in Supplementary Table S1and include literature review, meta-analysis, evaluation of clinical evidence from a large treating center and pooled analysis of individual patient-level data collected from a of sites.

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Table 1 Demographics and patient characteristics—historical comparator and clinical trial data Full size table The demographic and clinical characteristics of the blinatumomab clinical trial population varied on several Gold coast-tweed united girls compared with the Horney clearlake women. data.

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Estimates of complete remission cr and overall survival os were weighted by the frequency distribution of prognostic factors in the blinatumomab trial. texas black history calendar

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In the estimation of treatment effects, propensity scores were used to adjust for differences between patients in the blinatumomab clinical trial and patients in the historical data set using inverse probability of treatment weighting IPTW methods.

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